El psicópata Michael Myers sigue vivo y vuelve a ponerse en acción. Ahora se dirige a un pequeño hospital donde se encuentra Laurie Strode, la única víctima que logró sobrevivir a su primer ataque. Mientras tanto, el doctor Loomis sigue buscando a su sanguinario paciente.

After failing to kill stubborn survivor Laurie and taking a bullet or six from former psychiatrist Dr. Sam Loomis, Michael Myers has followed Laurie to the Haddonfield Memorial Hospital, where she's been admitted for Myers' attempt on her life. The institution proves to be particularly suited to serial killers, however, as Myers cuts, stabs and slashes his way through hospital staff to reach his favorite victim.