Los detectives de narcóticos Mike Lowrey y Marcus Burnett han sido asignados a un nuevo caso en Miami, donde un astuto narcotraficante ha iniciado una sangrienta guerra. Además la amistad de los dos agentes se complica cuando Mike empieza a sentir algo por la hermana de Marcus...

Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug Ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.